Genomic location: Pf3D7_14_v3:17,469..18,808(-)
Miles Classification: SubtelomericHypervariable
Product Description: rifin
SignalP Peptide: MKVHYTKILLFSLPLNILVTSSSNA
# Transmembrane Domains: 1
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0020002 | host cell plasma membrane |
| Process | GO:0020033 | antigenic variation |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IM83
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 339 | Molecular Weight (kDa): 37.662
UniProt ID(s): Q8IM83
PDB ID(s): None
Isoelectric Point: 9.74
Protein Domain Annotations:
| InterPro | IPR006373 | Variant surface antigen Rifin |
| PFam | PF02009 | Variant surface antigen Rifin |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1400500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 505
Non-coding: 118 | Synonymous: 116 | Nonsynonymous: 265 | Stop Codon: 6
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 10430943 | Rifins: a second family of clonally variant proteins expressed on the surface ofred cells infected with Plasmodium falciparum. | Kyes SA, Rowe JA, Kriek N, Newbold CI | 10.1073/pnas.96.16.9333 |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |