PF3D7_1407400

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Essentiality

Zhang Phenotype: Non - Mutable in CDS

• Mutagenesis Index Score (MIS): 0.185
• Mutagenesis Fitness Score (MFS): -2.718
• Number of insertions in CDS: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1034800)

• Relative Growth Rate: 1.00 ± 0.15
• Confidence: 5.20

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1034800)

• Gene Modification: Disrupted
• RMgmDB ID Link: RMgm-2887

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IM20

"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=1.60) with 6KCK (Global RMSD=27.20)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533709

No human ortholog(s)

Protein Information

Protein length: 194 | Molecular Weight (kDa): 23.667

UniProt ID(s): Q8IM20

PDB ID(s): None

Isoelectric Point: 9.45

Protein Domain Annotations:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1407400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 200

Non-coding: 177 | Synonymous: 12 | Nonsynonymous: 10 | Stop Codon: 1

Associated Publications