Genomic location: Pf3D7_14_v3:487,436..490,380(-)
Miles Classification: Core
Product Description: MORN repeat protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.1.1.43 (Transferred entry: 2.1.1.354)
Curated GO (PlasmoDB):
| Component | GO:0005829 | cytosol |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1030400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1030400)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILX2
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| 2.1.1.43 | histone-lysine N-methyltransferase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Protein length: 760 | Molecular Weight (kDa): 89.335
UniProt ID(s): Q8ILX2
PDB ID(s): None
Isoelectric Point: 7.34
Protein Domain Annotations:
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF82185 | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1412200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 47 | 24 | 44 |
| disruptive | 12 | 106 | 66 | 176 |
| missense | 12 | 104 | 64 | 167 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 88 | 25 | 59 |
| disruptive | 27 | 264 | 109 | 217 |
| missense | 25 | 234 | 99 | 167 |
PlasmoDB Total SNPs: 124
Non-coding: 77 | Synonymous: 24 | Nonsynonymous: 23 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |