Genomic location: Pf3D7_14_v3:1,638,717..1,641,760(+)
Miles Classification: Core
Product Description: porphobilinogen synthase
SignalP Peptide: MLKSDVVLLLYILIINLICC
# Transmembrane Domains: 0
EC Numbers: 4.2.1.24 (Porphobilinogen synthase)
Curated GO (PlasmoDB):
| Component | GO:0020011 | apicoplast |
| Component | GO:0005829 | cytosol |
| Function | GO:0004655 | porphobilinogen synthase activity |
| Function | GO:0008270 | zinc ion binding |
| Process | GO:0006783 | heme biosynthetic process |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1304100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL68
"Best" AlphaFill ligand hit: PBG (3-[5-(aminomethyl)-4-(carboxymethyl)-1h-pyrrol-3-yl]propanoic acid, Local RMSD=0.28) with 3OBK (Global RMSD=13.06)
BRENDA EC Inhibitors:
| 4.2.1.24 | porphobilinogen synthase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101254
Most Similar Human Ortholog: P13716
All Human Orthologs (OrthoMCL):
| ENSG00000148218 | aminolevulinate dehydratase |
Protein length: 451 | Molecular Weight (kDa): 53.188
UniProt ID(s): Q8IL68, Q8MTV7, Q8MYK5, Q9U0R8
PDB ID(s): None
Isoelectric Point: 8.52
Protein Domain Annotations:
| InterPro | IPR001731 | Delta-aminolevulinic acid dehydratase |
| InterPro | IPR030656 | Delta-aminolevulinic acid dehydratase, active site |
| PFam | PF00490 | Delta-aminolevulinic acid dehydratase |
| Superfamily | SSF51569 | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1440300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 24 | 15 | 29 |
| disruptive | 7 | 27 | 26 | 63 |
| missense | 7 | 27 | 25 | 61 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 50 | 20 | 30 |
| disruptive | 14 | 72 | 52 | 100 |
| missense | 12 | 68 | 47 | 80 |
PlasmoDB Total SNPs: 156
Non-coding: 141 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15144063 | Enzymes for heme biosynthesis are found in both the mitochondrion and plastid ofthe malaria parasite Plasmodium falciparum. | Sato S, Clough B, Coates L, Wilson RJ | 10.1078/1434461000169 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 36823845 | Wide-angle high-efficiency absorption of graphene empowered by anangle-insensitive Tamm plasmon polariton | Wu F, Xiao S | 10.1364/OE.481668 |
| 38038118 | Periodic and quasi-periodic one-dimensional extrinsically magnetized photoniccrystals with robust photonic bandgaps | Biswal A | 10.1364/AO.502541 |
| 38183271 | Mechanochromic and Solvomechanochromic Fluorescent Photonic Crystals forDual-Mode Modulating Fluorescence and Multilevel Anticounterfeiting | Liu J, Ma D, ..., Huang S | 10.1021/acsami.3c15120 |
| 37723700 | Dirac points, new photonic band gaps, and effect of magnetically inducedtransparency in dichroic cholesteric liquid crystals with wavelength-dependentmagneto-optical activity parameter | Gevorgyan AH | 10.1103/PhysRevE.108.024703 |
| 37543355 | Endovascular Versus Surgical Treatment for All Comer Patients With ProstheticBypass Graft Occlusion: The Multicentre ENSUPRO Study | Korosoglou G, Torsello G, ..., Stavroulakis K | 10.1016/j.ejvs.2023.07.054 |
| 38320197 | Biliary stem cells in health and cholangiopathies and cholangiocarcinoma | Cardinale V, Paradiso S, Alvaro D | 10.1097/MOG.0000000000001005 |
| 37071336 | Biochemical and molecular characterization of a novel porphobilinogen synthasefrom Corynebacterium glutamicum | Zhu D, Wu C, ..., Li W | 10.1007/s11274-023-03615-2 |
| 37863644 | One ring closer to a closure: the crystal structure of the ES(3)hydroxymethylbilane synthase intermediate | Bustad HJ, Christie MS, ..., Kallio JP | 10.1111/febs.16982 |
| 37262274 | Angle-insensitive topological interface states in hybrid one-dimensional photoniccrystal heterostructures containing all-dielectric metamaterials | Wu F, Li H, ..., Long Y | 10.1364/OL.493788 |
| 37010824 | A redshifted photonic bandgap and wide-angle polarization selection in anall-hyperbolic-metamaterial one-dimensional photonic crystal | Wu F, Liu D, Li H, Feng M | 10.1039/d3cp00280b |
| 36821275 | Polarization-sensitive photonic bandgaps in hybrid one-dimensional photoniccrystals composed of all-dielectric elliptical metamaterials and isotropicdielectrics | Wu F, Liu T, Xiao S | 10.1364/AO.480083 |
| 37651586 | Development of pancreatic islet cells in the extrahepatic bile ducts of rats withexperimentally-induced metabolic syndrome | Gulubova M, Tolekova A, Berbatov D, Aydogdu N | 10.1080/13813455.2023.2252205 |
| 36721302 | Restoration of Bile Duct Injury of Donor Livers During Ex Situ NormothermicMachine Perfusion | de Jong IEM, Bodewes SB, ..., Porte RJ | 10.1097/TP.0000000000004531 |
| 36609630 | Multiplication of photonic band gaps in one-dimensional photonic crystals byusing hyperbolic metamaterial in IR range | Mohamed AG, Sabra W, ..., Elsayed HA | 10.1038/s41598-023-27550-2 |
| 37708358 | Novel BODIPY-Based Photobase Generators for Photoinduced Polymerization | Yu S, Reddy O, ..., Zhang Y | 10.1021/acsami.3c09326 |
| 37706794 | Ultra-large near-infrared omnidirectional photonic bandgaps in cascadedone-dimensional photonic crystals containing all-dielectric metamaterials | Cheng Z, She Y, ..., Wu F | 10.1364/AO.496519 |
| 37376270 | Surface-Enhanced Raman Scattering (SERS) Substrates Based on Ag-Nanoparticles andAg-Nanoparticles/Poly (methyl methacrylate) Composites | Matamoros-Ambrocio M, Sanchez-Mora E, Gomez-Barojas E | 10.3390/polym15122624 |
| 36538478 | Wave propagation and band tails of two-dimensional disordered systems in thethermodynamic limit | Klatt MA, Steinhardt PJ, Torquato S | 10.1073/pnas.2213633119 |
| 38048275 | Transparent Patternable Large-Area Graphene p-n Junctions by PhotoinducedElectron Doping | Kirihara K, Okigawa Y, ..., Wei Q | 10.1021/acsami.3c12419 |
| 37528116 | A postnatal network of co-hepato/pancreatic stem/progenitors in the biliary treesof pigs and humans | Zhang W, Wang X, ..., Reid LM | 10.1038/s41536-023-00303-5 |