Genomic location: Pf3D7_14_v3:1,704,178..1,705,128(+)
Miles Classification: Core
Product Description: RNA polymerase II transcription factor B subunit 5, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.7.6 (DNA-directed RNA polymerase)
Curated GO (PlasmoDB):
| Component | GO:0005669 | transcription factor TFIID complex |
| Component | GO:0000439 | transcription factor TFIIH core complex |
| Component | GO:0005675 | transcription factor TFIIH holo complex |
| Process | GO:0006289 | nucleotide-excision repair |
| Process | GO:0006294 | nucleotide-excision repair, preincision complex assembly |
| Process | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain |
| Process | GO:0006366 | transcription by RNA polymerase II |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS *tentative
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IL51
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| 2.7.7.6 | DNA-directed RNA polymerase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104325
Most Similar Human Ortholog: Q6ZYL4
All Human Orthologs (OrthoMCL):
| ENSG00000272047 | general transcription factor IIH subunit 5 |
Protein length: 67 | Molecular Weight (kDa): 7.855
PDB ID(s): None
Isoelectric Point: 4.37
Protein Domain Annotations:
| InterPro | IPR009400 | TFIIH subunit TTDA/Tfb5 |
| InterPro | IPR035935 | TFB5-like superfamily |
| PFam | PF06331 | TFIIH subunit TTDA/Tfb5 |
| Superfamily | SSF142897 | TFB5-like superfamily |
Old (Pf3D7v3) Gene ID: PF3D7_1441900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 46
Non-coding: 45 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 26102503 | Twilight, a Novel Circadian-Regulated Gene, Integrates Phototropism with Nutrientand Redox Homeostasis during Fungal Development | Deng YZ, Qu Z, Naqvi NI | 10.1371/journal.ppat.1004972 |
| 22308316 | Subunit architecture of general transcription factor TFIIH | Gibbons BJ, Brignole EJ, ..., Kornberg RD | 10.1073/pnas.1105266109 |
| 19156361 | In silico construction of a protein interaction landscape for nucleotide excisionrepair | Tran N, Qu PP, ..., Kaufmann WK | 10.1007/s12013-009-9042-y |
| 15220921 | A new, tenth subunit of TFIIH is responsible for the DNA repair syndrometrichothiodystrophy group A | Giglia-Mari G, Coin F, ..., Vermeulen W | 10.1038/ng1387 |
| 25016283 | TTDA: big impact of a small protein | Theil AF, Hoeijmakers JH, Vermeulen W | 10.1016/j.yexcr.2014.07.008 |
| 15220919 | Identification of TFB5, a new component of general transcription and DNA repairfactor IIH | Ranish JA, Hahn S, ..., Aebersold R | 10.1038/ng1385 |
| 32776683 | The basal transcription factor II H subunit Tfb5 is required for stress responseand pathogenicity in the tangerine pathotype of Alternaria alternata | Fu H, Chung KR, ..., Li H | 10.1111/mpp.12982 |
| 20606254 | Structure determination of the minimal complex between Tfb5 and Tfb2, twosubunits of the yeast transcription/DNA-repair factor TFIIH: a retrospectivestudy | Kainov DE, Cura V, ..., Poterszman A | 10.1107/S0907444910009844 |
| 23637614 | Disruption of TTDA results in complete nucleotide excision repair deficiency andembryonic lethality | Theil AF, Nonnekens J, ..., Vermeulen W | 10.1371/journal.pgen.1003431 |
| 17409062 | Suppression of the Schizosaccharomyces pombe cut12.1 cell-cycle defect bymutations in cdc25 and genes involved in transcriptional and translationalcontrol | Tallada VA, Bridge AJ, Emery PA, Hagan IM | 10.1534/genetics.107.072090 |
| 19172752 | Structural basis for group A trichothiodystrophy | Kainov DE, Vitorino M, ..., Egly JM | 10.1038/nsmb.1478 |
| 17215295 | Tfb5 interacts with Tfb2 and facilitates nucleotide excision repair in yeast | Zhou Y, Kou H, Wang Z | 10.1093/nar/gkl1085 |
| 19897425 | Interacting partners of the Tfb2 subunit from yeast TFIIH | Kainov DE, Selth LA, ..., Poterzsman A | 10.1016/j.dnarep.2009.10.002 |
| 17644494 | Tfb5 is partially dispensable for Rad26 mediated transcription coupled nucleotideexcision repair in yeast | Ding B, Ruggiero C, Chen X, Li S | 10.1016/j.dnarep.2007.06.001 |