PF3D7_1442700

Genomic location: Pf3D7_14_v3:1,742,097..1,750,189(+)

Miles Classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

N/A

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Zhang Phenotype: Mutable in CDS

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

AlphaFill Uniprot ID: Q8IL44

"Best" AlphaFill ligand hit: RHQ (rhodamine 6g, Local RMSD=2.56) with 3BR5 (Global RMSD=42.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Ortholog Group (OrthoMCL): OG6_532476

No human ortholog(s)

Protein length: 2511 | Molecular Weight (kDa): 300.98

UniProt ID(s): Q8IL44

PDB ID(s): None

Isoelectric Point: 9.62

Protein Domain Annotations:

Old (Pf3D7v3) Gene ID: PF3D7_1442700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	20	105	66	170
disruptive	103	466	254	603
missense	91	438	245	541

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	33	226	106	187
disruptive	202	882	383	653
missense	155	807	350	544

PlasmoDB Total SNPs: 273

Non-coding: 42 | Synonymous: 100 | Nonsynonymous: 128 | Stop Codon: 3

PMID	Title	Authors	DOI
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097