About Gene List Toggle Layout

PF3D7_1449100

Genomic location: Pf3D7_14_v3:2,007,923..2,013,037(+)

Miles Classification: Core

Function and Localization

Product Description: CLASP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: N/A

Curated GO (PlasmoDB):

Component GO:0005881 cytoplasmic microtubule
Component GO:0005634 nucleus
Function GO:0008017 microtubule binding
Process GO:0000226 microtubule cytoskeleton organization

Expression by stage, third quartile (Malaria Cell Atlas): No data

More info:

Essentiality

Zhang Phenotype: Non - Mutable in CDS

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1312800)

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1312800)

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IKY3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_111884

No human ortholog(s)

Protein Information

Protein length: 1029 | Molecular Weight (kDa): 121.111

UniProt ID(s): Q8IKY3

PDB ID(s): None

Isoelectric Point: 8.72

Protein Domain Annotations:

InterPro IPR016024 Armadillo-type fold
InterPro IPR024395 CLASP N-terminal domain
PFam PF12348 CLASP N-terminal domain
Superfamily SSF48371 Armadillo-type fold

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1449100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 52 31 82
disruptive 41 201 119 252
missense 33 167 106 211

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 121 50 73
disruptive 86 424 179 364
missense 69 345 145 246

PlasmoDB Total SNPs: 298

Non-coding: 202 | Synonymous: 43 | Nonsynonymous: 52 | Stop Codon: 1

Associated Publications

PMID Title Authors DOI
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108