Genomic location: Pf3D7_14_v3:2,007,923..2,013,037(+)
Miles Classification: Core
Product Description: CLASP domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: N/A
Curated GO (PlasmoDB):
Component | GO:0005881 | cytoplasmic microtubule |
Component | GO:0005634 | nucleus |
Function | GO:0008017 | microtubule binding |
Process | GO:0000226 | microtubule cytoskeleton organization |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1312800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1312800)
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKY3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 1029 | Molecular Weight (kDa): 121.111
UniProt ID(s): Q8IKY3
PDB ID(s): None
Isoelectric Point: 8.72
Protein Domain Annotations:
InterPro | IPR016024 | Armadillo-type fold |
InterPro | IPR024395 | CLASP N-terminal domain |
PFam | PF12348 | CLASP N-terminal domain |
Superfamily | SSF48371 | Armadillo-type fold |
Old (Pf3D7v3) Gene ID: PF3D7_1449100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 52 | 31 | 82 |
disruptive | 41 | 201 | 119 | 252 |
missense | 33 | 167 | 106 | 211 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 12 | 121 | 50 | 73 |
disruptive | 86 | 424 | 179 | 364 |
missense | 69 | 345 | 145 | 246 |
PlasmoDB Total SNPs: 298
Non-coding: 202 | Synonymous: 43 | Nonsynonymous: 52 | Stop Codon: 1
PMID | Title | Authors | DOI |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |