Genomic location: Pf3D7_14_v3:2,059,507..2,067,011(-)
Miles Classification: Core
Product Description: E3 ubiquitin-protein ligase ZNF598, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.3.2.27 (RING-type E3 ubiquitin transferase)
Curated GO (PlasmoDB):
Component | GO:0005634 | nucleus |
Expression by stage, third quartile (Malaria Cell Atlas):
Ring: 2.17 | Trophozoite: 2.13 | Schizont: 1.82 | Gametocyte: 1.64
More info:
Zhang Phenotype: Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKX2
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
2.3.2.27 | RING-type E3 ubiquitin transferase | EDTADTPAMLN4924RAPTA-CRAPTA-TRAPTA-EA1 |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101580
Most Similar Human Ortholog: H3BPG6
All Human Orthologs (OrthoMCL):
ENSG00000167962 | zinc finger protein 598, E3 ubiquitin ligase |
Protein length: 1844 | Molecular Weight (kDa): 220.398
UniProt ID(s): Q8IKX2
PDB ID(s): None
Isoelectric Point: 8.92
Protein Domain Annotations:
InterPro | IPR001841 | Zinc finger, RING-type |
PFam | N/A | N/A |
Superfamily | SSF57850 | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1450400
Resistome Missense Mutations: E1267Q
Resistome Compounds with Missense Mutations: Lopinavir
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 25 | 145 | 79 | 149 |
disruptive | 62 | 258 | 153 | 354 |
missense | 48 | 212 | 136 | 300 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 59 | 246 | 113 | 169 |
disruptive | 123 | 605 | 268 | 640 |
missense | 82 | 469 | 209 | 472 |
PlasmoDB Total SNPs: 311
Non-coding: 121 | Synonymous: 106 | Nonsynonymous: 84 | Stop Codon: 0
PMID | Title | Authors | DOI |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |