Genomic location: Pf3D7_14_v3:2,151,389..2,154,604(-)
Miles Classification: Core
Product Description: syntaxin-6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0031201 | SNARE complex |
| Component | GO:0012505 | endomembrane system |
| Component | GO:0016021 | integral component of membrane |
| Component | GO:0005802 | trans-Golgi network |
| Function | GO:0005484 | SNAP receptor activity |
| Function | GO:0000149 | SNARE binding |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0048278 | vesicle docking |
| Process | GO:0006906 | vesicle fusion |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1316200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IKV1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101619
Most Similar Human Ortholog: F6RTM7
All Human Orthologs (OrthoMCL):
| ENSG00000104915 | syntaxin 10 |
| ENSG00000135823 | syntaxin 6 |
Protein length: 211 | Molecular Weight (kDa): 24.7
PDB ID(s): None
Isoelectric Point: 4.77
Protein Domain Annotations:
| InterPro | IPR000727 | Target SNARE coiled-coil homology domain |
| InterPro | IPR010989 | SNARE |
| InterPro | IPR015260 | Syntaxin 6, N-terminal |
| PFam | PF09177 | Syntaxin 6, N-terminal |
| Superfamily | SSF47661 | SNARE |
| Superfamily | SSF58038 |
Old (Pf3D7v3) Gene ID: PF3D7_1452500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 1 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 209
Non-coding: 197 | Synonymous: 9 | Nonsynonymous: 3 | Stop Codon: 0
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23962112 | Toxoplasma gondii Syntaxin 6 is required for vesicular transport betweenendosomal-like compartments and the Golgi complex. | Jackson AJ, Clucas C, ..., Meissner M | 10.1111/tra.12102 |
| 37996040 | Characterisation and prion transmission study in mice with genetic reduction ofsporadic Creutzfeldt-Jakob disease risk gene Stx6 | Jones E, Hill E, ..., Mead S | 10.1016/j.nbd.2023.106363 |
| 36071893 | Association between risk polymorphisms for neurodegenerative diseases andcognition in colombian patients with frontotemporal dementia | Lopez-Caceres A, Cruz-Sanabria F, ..., Matallana D | 10.3389/fneur.2022.675301 |
| 35842134 | Genetics of progressive supranuclear palsy in a Chinese population | Xiao X, Yang Q, ..., Shen L | 10.1016/j.nbd.2022.105819 |
| 37877357 | N(6) -methyladenosine-modified circSTX6 promotes hepatocellular carcinomaprogression by regulating the HNRNPD/ATF3 axis and encoding a 144 amino acidpolypeptide | Lu J, Ru J, ..., Wu J | 10.1002/ctm2.1451 |
| 37430358 | EDA ligand triggers plasma membrane trafficking of its receptor EDAR via PKAactivation and SNAP23-containing complexes | Yao Y, Yang R, ..., Sima J | 10.1186/s13578-023-01082-8 |
| 36612024 | Syntaxin-6, a Reliable Biomarker for Predicting the Prognosis of Patients withCancer and the Effectiveness of Immunotherapy | Li W, Li K, ..., Zhang C | 10.3390/cancers15010027 |
| 36291893 | Exponential Slope from Absolute Lymphocyte Counts during Radio-Chemotherapy CanPredict an Aggressive Course of Cervical Cancer | Cho O, Chun M, Chang SJ | 10.3390/cancers14205109 |
| 37218885 | Towards Understanding the Key Signature Pathways Associated from DifferentiallyExpressed Gene Analysis in an Indian Prostate Cancer Cohort | Shukla N, Kour B, ..., Suravajhala P | 10.3390/diseases11020072 |
| 36238841 | Role of STX6 as a prognostic factor associated with immune infiltration inhepatocellular carcinoma | Zhang Y, Li L, ..., Xiong J | 10.3892/ol.2022.13491 |
| 37564208 | Syntaxin-6 promotes the progression of hepatocellular carcinoma and alters itssensitivity to chemotherapies by activating the USF2/LC3B axis | Zhou L, Wang Z, ..., Li J | 10.7150/ijbs.86636 |
| 37993579 | In vitro evaluation of exocytosis-associated SNARE molecules in human granulosacells in polycystic ovary syndrome | Erol S, Zirh S, ..., Muftuoglu SF | 10.1007/s10815-023-02967-w |
| 36283703 | A high-content endogenous GLUT4 trafficking assay reveals new aspects ofadipocyte biology | Diaz-Vegas A, Norris DM, ..., Burchfield JG | 10.26508/lsa.202201585 |
| 37038700 | Chronic Obstructive Pulmonary Disease: Novel Genes Detection with PenalizedLogistic Regression | Gohari K, Kazemnejad A, ..., Sheidaei A | 10.22074/cellj.2022.557389.1048 |
| 35862696 | Human Cytomegalovirus Manipulates Syntaxin 6 for Successful Trafficking andSubsequent Infection of Monocytes | Mosher BS, Fulkerson HL, ..., Yurochko AD | 10.1128/jvi.00819-22 |
| 36982356 | Genetics of Multiple System Atrophy and Progressive Supranuclear Palsy: ASystemized Review of the Literature | Bougea A | 10.3390/ijms24065281 |
| 37378930 | Syntaxin 6 Enhances the Progression of Epithelial Ovarian Cancer by PromotingCancer Cell Proliferation | Zhang W, Lv Q, Lu D, Chen F | 10.31557/APJCP.2023.24.6.2003 |
| 36747809 | A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretionfrom endothelial cells | Kinghorn K, Gill A, ..., Bautch VL | 10.1101/2023.01.27.525517 |
| 38314938 | Novel Insights into the Genetic Basis of Progressive Supranuclear Palsy inAsian-Indian Population | Dey S, Debnath M, ..., Yadav R | 10.1002/mds.29740 |
| 38234807 | Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and StructuralVariants Associated with Progressive Supranuclear Palsy | Wang H, Chang TS, ..., Lee WP | 10.1101/2023.12.28.23300612 |
| 37695358 | A defined clathrin-mediated trafficking pathway regulates sFLT1/VEGFR1 secretionfrom endothelial cells | Kinghorn K, Gill A, ..., Bautch VL | 10.1007/s10456-023-09893-6 |