Genomic location: Pf3D7_14_v3:3,282,729..3,283,752(+)
Miles Classification: SubtelomericHypervariable
Product Description: stevor
SignalP Peptide: MNMYYLNMLLFTFLINTLL
# Transmembrane Domains: 3
EC Numbers: N/A
Curated GO (PlasmoDB):
| Component | GO:0020036 | Maurer's cleft |
| Process | GO:0020013 | modulation by symbiont of host erythrocyte aggregation |
Expression by stage, third quartile (Malaria Cell Atlas): No data
More info:
Zhang Phenotype: Non - Mutable in CDS
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A3E5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Protein length: 304 | Molecular Weight (kDa): 34.488
UniProt ID(s): A0A144A3E5, Q2XR13, Q2XR15
PDB ID(s): None
Isoelectric Point: 8.52
Protein Domain Annotations:
| InterPro | IPR006374 | Variant surface antigen Stevor |
| PFam | PF17410 | Variant surface antigen Stevor |
| Superfamily | N/A | N/A |
Old (Pf3D7v3) Gene ID: PF3D7_1479900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 472
Non-coding: 53 | Synonymous: 129 | Nonsynonymous: 287 | Stop Codon: 3
| PMID | Title | Authors | DOI |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |
| 12477793 | Small variant STEVOR antigen is uniquely located within Maurer's clefts inPlasmodium falciparum-infected red blood cells. | Kaviratne M, Khan SM, Jarra W, Preiser PR | 10.1128/EC.1.6.926-935.2002 |
| 25011110 | STEVOR is a Plasmodium falciparum erythrocyte binding protein that mediatesmerozoite invasion and rosetting. | Niang M, Bei AK, ..., Preiser PR | 10.1016/j.chom.2014.06.004 |